Circulating levels of Interferon regulatory Factor-5 correlates with disease activity in Systemic Lupus Erythematosus Iraqi patients
نویسندگان
چکیده
Objectives: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by diversity of the phenotypes among patients. SLE still one great challenges due to lacking specific biomarkers for diagnosis, assessing activity, and prediction response therapy. This study aimed investigate role circulating levels IRF5 protein in sample Iraqi patients its correlation with identify potential immunological biomarker mirror activity.
 Methods: Blood samples were taken from 59 participants diagnosed cases classified according American College Rheumatology (ACR) criteria. They scored through activity index 2000 (SLEDAI-2K) estimate it they subdivided into “SLE-1 group” (SLEDAI-2k ≤5), “SLE-2 >5), as well age gender matched healthy control group. Circulating measured sera ELISA method.
 Results: Our result revealed that significantly higher SLE-2 group rather than (p<0.01), while there was non-significant difference between SLE-1 (p>0.05), both patient groups. Moreover, found be correlated positively The other parameters significant positive ESR globulins, negative Hb (albumin/ globulin) ratio, urea, creatinine, uric acid. analysis receiver operator curves (ROC) groups showed good accuracy distinguish individuals (AUC=0.758, sensitivity=65.5%, specificity=69%,), (AUC=0.788, sensitivity=77.3%, specificity=72.0%,), respectively.
 Conclusions: correlate reflects possibility using monitoring activity.
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ژورنال
عنوان ژورنال: Journal of contemporary medical sciences
سال: 2022
ISSN: ['2413-0516', '2415-1629']
DOI: https://doi.org/10.22317/jcms.v8i6.1299